Treatment and prevention of vitamin E deficiency (diet of vitamin E deficiency, children with pancreatic cystic fibrosis or fat malabsorption due to biliary atrophy or lack of blood betalipoprotein, premature low birth weight babies at birth) .
The main signs of vitamin E deficiency include neuromuscular manifestations such as decreased reflexes, abnormal gait, decreased sensitivity to vibration and receptors, ocular paralysis, and retinopathy. neurotransmitter
CONTENTS OF USE OF MEDICINE USE TO HEALTH OFFICERS
INGREDIENT COMPONENTS OF MEDICINE:
Vitamin E (dl-alpha tocopheryl acetate) ............. 400 IU
Excipients q.s ... .. 1 member
(Refined soybean oil, gelatin 150 bloom, sorbitol liquid, glycerin, potassium sorbate, vanillin).
DOSAGE FORM: Soft capsules.
PHARMACODYNAMIC:
ATC CODE: A11HA03
Vitamin E is an oil-soluble vitamin, widely distributed in food. The richest sources of vitamin E are vegetable oils, especially wheat germ oil, sunflower oil, and cotton seed oil; Cereals and eggs are also a rich source of vitamin E.
The amount of vitamin E in food is lost due to storage and cooking. The daily requirement for vitamin E is about 4 - 15 mg.
Vitamin E deficiency is rare, occurring only in people who are unable to absorb vitamin E or suffer from a number of genetic diseases that prevent the maintenance of normal levels of vitamin E in the blood.
The exact biological function of vitamin E is not fully known in humans. Vitamin E is considered an antioxidant. Vitamin E prevents the oxidation of unsaturated fatty acids as well as other oxygen-sensitive substances such as vitamin A and vitamin C. Free radicals are generated by many cellular reactions damaging cell membranes, proteins and nuleic acid, leading to dysfunction and cell disease. Vitamin E reacts with free radicals, losing peroxyl radicals. In the reaction process, vitamin E does not create other free radicals.
Due to the antioxidant properties of vitamin E, there have been many studies using vitamin E to alleviate dementia of early Alzheimer's disease or due to aging, age-related macular degeneration, cancer. , arteriosclerosis, coronary artery disease, cataracts, ... but so far have not been clearly proven effective.
PHARMACOKINETICS: Absorption: In order for vitamin E to be absorbed in the gastrointestinal tract, bile and pancreas must function normally. The amount of vitamin E uptake decreases with increasing doses. About 20 - 60% of the vitamin is absorbed from the food source. In patients with poor absorption syndrome and low birth weight infants, vitamin E absorption can be greatly reduced. Water-dispersed preparations can be absorbed better through the intestine than oily formulations.
Distribution: The drug enters the bloodstream through the microscopic acceptor in the lymph and is then transported to the liver. Vitamin E is secreted from the liver in the form of low density lipoprotein (VLDL) and the concentration of vitamin E in plasma depends on this secretion. Only one form of R-alpha-tocopherol isomer is re-released by the liver thanks to its affinity for the liver's alpha-tocopherol transport protein. Vitamin E is then widely distributed into all tissues and stored in adipose tissue. The normal concentration of tocoferol in plasma is 6-14 micrograms / ml or less than 800 micrograms of vitamin E / g lipid in plasma for several months as a reflection of vitamin E deficiency. , plasma tocopherol concentration may be elevated in 1-2 days. The total vitamin E reserves in the body is estimated at 3 - 8 g and can meet the body needs for 4 years or more when the diet is poor in vitamin. Alpha tocopherol is distributed into the eye, achieving a higher concentration in the cornea than the choroid or lens. This concentration may increase with vitamin supplements. Vitamin E enters milk, but very little crosses the placenta. Infant plasma tocopherol concentration is 20 - 30% of the concentration in mothers and lower birth weight infants.
Elimination: Vitamin E is converted in the liver to the glucoronides of tocopheronic acid and gamma-lactones of this acid, most of the dose is slowly eliminated in bile. Some excreted in urine.
PRESENTATION: Box of 10 blisters x 10 soft capsules.
INDICATIONS: Treatment and prevention of vitamin E deficiency (diet of vitamin E deficiency, children with pancreatic cystic fibrosis or fat malabsorption due to bile duct atrophy or lack of blood betalipoprotein, low birth weight infants) at birth).
The main signs of vitamin E deficiency include neuromuscular manifestations such as decreased reflexes, abnormal gait, decreased sensitivity to vibration and receptors, ocular paralysis, and retinopathy. factor, neurodegenerative degeneration.
DOSAGE AND ADMINISTRATION: Treatment and prevention of vitamin E deficiency: Take 1 capsule once daily, after a meal.
CONTRAINDICATIONS: Hypersensitivity to any components of the drug.
PRECAUTIONS: The incidence of necrotizing enterocolitis should be considered when treating vitamin E for preterm infants weighing less than 1.5 kg.
High doses of vitamin E have been reported to tend to cause bleeding in patients with vitamin K deficiency or taking anticoagulants.
The effects of vitamin E have been largely studied only for a few weeks or months, so the lifelong chronic effects of long-term, high doses remain unclear. However, caution should be exercised when treating and attention should be paid to high doses of vitamin E above 400 IU / day or higher in people with chronic illnesses that are associated with an increase in all-cause mortality.
Pregnant women: During pregnancy, deficiency or excess of vitamin E are not causing complications for the mother or fetus. Vitamin E needs of pregnant women and normal women are no different. In a well-nourished mother, the amount of vitamin E in food is sufficient and does not require supplementation. If your diet is poor, supplement your daily needs during pregnancy.
Lactating women: Vitamin E in milk. Human milk has 5 times the amount of vitamin E of cow's milk and is more effective in maintaining adequate serum vitamin E levels for children up to 1 year of age.
The daily requirement of vitamin E during breastfeeding is 19 mg. Just supplement for mothers when the menu does not provide enough vitamin E needed for daily needs.
Effects of drugs on work: It does not affect people who are operating machinery, driving trains, people working on high altitude and other cases.
INTERACTIONS: Vitamin E or metabolite reduces the effectiveness of vitamin K and increases the effectiveness of anticoagulants.
Concurrent use of vitamin E and acetylsalicylic acid may cause bleeding.
Vitamin E can increase the absorption, use and storage of vitamin A. Vitamin E protects vitamin A from oxidative degeneration resulting in increased levels of vitamin A in cells; vitamin E also protects against the effects of excess vitamin A. However, these effects are controversial.
Vitamin E doses above 10 IU / kg may slow the response of iron therapy in iron-deficiency anemia children. Iron-fortified newborn babies can increase hemolytic anemia due to vitamin E deficiency.
Excessive use of mineral oil may reduce the absorption of vitamin E.
Colestyramine, colestipol, orlistat can interfere with absorption of vitamin E. Use at least 2 hours apart.
ADVERSE EFFECTS (ADR):
Vitamin E is generally well tolerated. ADR can occur when high doses, prolonged, intravenous, especially when used for premature, low birth weight babies.
CNS: Headache, dizziness.
Eyes: Blurred vision.
Gastrointestinal: Nausea, diarrhea, abdominal pain, digestive disorders, necrotizing enterocolitis.
Endocrine and metabolic: Abnormal gonads, breast tenderness, increased cholesterol and serum triglycerides, decreased thyroxin and serum triiodothyronin.
Kidney: Creatinuria, increase in serum creatin kinase, increase in estrogen and androgen in the urine.
Other: Rash, dermatitis, fatigue, thrombophlebitis.
OVERDOSE AND TREATMENT: There have been no reports of overdose on vitamin E.
Read the directions carefully before use.
If you need further information, please consult your doctor.
STORAGE CONDITIONS: Store in dry places, temperature not exceeding 30oC, protect from light.
SHELF LIFE: 36 months from date of manufacture.
CONTENTS OF DRUGS USED FOR PATIENT
Read the directions carefully before use.
Keep out of reach of CHILDREN.
Immediately inform your doctor or pharmacist of any unwanted effects encountered when using the drug.
INGREDIENT, CONTENT OF MEDICINE:
Vitamin E (dl-alpha tocopheryl acetate) ... 400 IU
Excipients 1 capsule
(Refined soybean oil, gelatin 150 bloom, sorbitol liquid, glycerin, potassium sorbate, vanillin).
PRODUCT DESCRIPTION: Soft oval capsule, pale yellow, inside contains a clear solution.
PRESENTATION: Box of 10 blisters x 10 soft capsules.
WHAT IS THE MEDICINE USED FOR? Vitamin E acts as an antioxidant, helping to protect cells from damage caused by the oxidation of free radicals.
Treatment and prevention of vitamin E deficiency
HOW TO USE THIS MEDICINE AND DOSAGE:
Administration: Oral administration.
Dosage and administration: 1 capsule once daily, after a meal.
WHEN SHOULD NOT TAKE THIS MEDICINE:
Hypersensitivity to any component of the medication.
ADVERSE EFFECTS (ADR): Vitamin E is generally well tolerated. ADR can occur when high doses, prolonged, intravenous, especially when used for premature, low birth weight babies.
CNS: Headache, dizziness.
Eyes: Blurred vision.
Gastrointestinal: Nausea, diarrhea, abdominal pain, digestive disorders, necrotizing enterocolitis.
Endocrine and metabolic: Abnormal gonads, breast tenderness, increased cholesterol and serum triglycerides, decreased thyroxin and serum triiodothyronin.
Kidney: Creatinuria, increase in serum creatin kinase, increase in estrogen and androgen in the urine.
Other: Rash, dermatitis, fatigue, thrombophlebitis.
WHAT DRUGS OR FOODS AVOIDES AVOID TO AVOID WHEN USING THIS MEDICINE: Vitamin E or its metabolite reduces the effectiveness of vitamin K and increases the effectiveness of anticoagulants.
Concurrent use of vitamin E and acetylsalicylic acid may cause bleeding.
Vitamin E can increase the absorption, use and storage of vitamin A. Vitamin E protects vitamin A from oxidative degeneration resulting in increased levels of vitamin A in cells; vitamin E also protects against the effects of excess vitamin A. However, these effects are controversial.
Vitamin E doses above 10 IU / kg may slow the response of iron therapy in iron-deficiency anemia children. Iron-fortified newborn babies can increase hemolytic anemia due to vitamin E deficiency.
Excessive use of mineral oil may reduce the absorption of vitamin E.
Colestyramine, colestipol, orlistat can interfere with absorption of vitamin E. Use at least 2 hours apart.
What to do when you forget to use drugs:
Take the next dose as directed. Do not use extra medicine to make up the missed dose to avoid overdose.
HOW TO STORAGE THIS MEDICINE:
Store in dry places, not exceeding 30oC, protect from light.
SIGNS AND SYMPTOMS WHEN USING OVERDOSE DRUGS:
There have been no reports of overdose on vitamin E.
WHAT TO DO WHEN USING DRUGS TOO MUCH RECOMMENDED:
There have been no reports of overdose on vitamin E.
IMPORTANT THINGS WHEN USING THIS MEDICINE:
The incidence of necrotizing enterocolitis should be considered when treating vitamin E for preterm infants weighing less than 1.5 kg.
High doses of vitamin E have been reported to tend to cause bleeding in patients with vitamin K deficiency or taking anticoagulants.
The effects of vitamin E have been largely studied only for a few weeks or months, so the lifelong chronic effects of long-term, high doses remain unclear. However, caution should be exercised when treating and attention should be paid to high doses of vitamin E above 400 IU / day or higher in people with chronic illnesses that are associated with an increase in all-cause mortality.
Pregnant:
During pregnancy, deficiency or excess of vitamin E does not cause complications for the mother or fetus. Vitamin E needs of pregnant women and normal women are no different. In a well-nourished mother, the amount of vitamin E in food is sufficient and does not require supplementation. If the diet is poor, supplement your daily needs during pregnancy.
Lactating women:
Vitamin E into milk. Human milk has 5 times the amount of vitamin E of cow's milk and is more effective in maintaining adequate serum vitamin E levels for children up to 1 year of age.
The daily requirement of vitamin E during breastfeeding is 19 mg. Just supplement for mothers when the menu does not provide enough vitamin E needed for daily needs.
Effects of drugs on work: It does not affect people who are operating machinery, driving trains, people working on high altitude and other cases.
WHEN TO CONSULT YOUR DOCTOR, PHARMACY: If you need more information, please consult your doctor or pharmacist.
SHELF-LIFE OF MEDICINE: 36 months from date of manufacture.
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Treatment of skin-borne fungal infections such as: fungal infections of the body (strabismus, tarpaulin), fungal infections in the groin, fungus in the hands and feet. Treatment of skin and ringworm Candida. Used in seborrheic dermatitis (skin pathology related to the fungus Pityrosporum ovale).
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Diseases of skin pathology in cases of darkening, freckles, dry skin, ... Use in case of dry, brittle, brittle hair. Treatment in cases of drug-induced dermatitis, allergies, acne, seborrheic dermatitis. Treatment of corneal injuries caused by trauma, chemicals, bacterial or viral infections.
